Module Catalogues, Xi'an Jiaotong-Liverpool University   
 
Module Code: CHE310
Module Title: Introduction to Medicinal Chemistry
Module Level: Level 3
Module Credits: 2.50
Academic Year: 2017/18
Semester: SEM2
Originating Department: Chemistry
Pre-requisites: N/A
   
Aims
The aim of this module is to introduce students to the fundamental principles that underpin modern medicinal chemistry, including an introduction to targets for drug action, methods of administration, qualitative and quantitative SAR, computer aided molecular design, solid phase chemistry /combinatorial chemistry. The course also aims to describe in detail the chemical mechanisms of antitumour agents.
Learning outcomes 
By the end of this module students are expected to have acquired an understanding of

- The principle bonding interactions in drug receptor interactions The basic concepts of structure activity relationships (SAR) and quantitative structure activity relationships (QSAR)

- The principles behind computer aided molecular design and 3-D QSAR

- Peptide synthesis, protecting groups and combinatorial chemistry - Chemical mechanisms of drugs that target DNA

- and will be able to use these concepts and principles to solve simple problems in medicinal chemistry
Method of teaching and learning 
This course will be taught by a series of lectures in Chemistry. Students will learn how to apply their knowledge by completing a series of related tutorials.
Syllabus 
Topics will include: 1. Introduction to Medicinal Chemistry: Overview of Targets for Drug Action 2. Methods of Administration: The Pharmaceutical Phase 3. Structures of Proteins: Bonds/ Energies Involved in Drug Receptor Interactions 4. Structure Activity Relationships (SAR I) 5. (SARII): Fluorine Substitution in Medicinal Chemistry 6. Quantitative Structure Activity Relationships (QSAR) 7. Computer Aided Molecular Design : 3D-QSAR 8. Peptide Synthesis: Protecting Group Strategy in Synthesis 9. Combinatorial Chemistry 1 10. Combinatorial Chemistry II 11. Drug Design – Solubility, Membrane Permeability 12. Drug Design – Targeting Drugs 13. DNA as a Target for Drugs 14. Chemical Mechanisms of Anticancer Drugs.
Delivery Hours  
Lectures Seminars Tutorials Lab/Prcaticals Fieldwork / Placement Other(Private study) Total
Hours/Semester 13     7      55  75 

Assessment

Sequence Method % of Final Mark
1 Final Exam 80.00
2 Assignment 20.00

Module Catalogue generated from SITS CUT-OFF: 10/22/2017 9:32:36 PM