Module Catalogues, Xi'an Jiaotong-Liverpool University   
 
Module Code: CHE207
Module Title: Preparative Chemistry: Synthesis and Characterisation
Module Level: Level 2
Module Credits: 5.00
Academic Year: 2017/18
Semester: SEM1
Originating Department: Chemistry
Pre-requisites: CHE101 CHE103
   
Aims
The module aims to present a unified approach to the synthesis and characterisation of organic, organometallic and inorganic compounds and will build on techniques introduced in the first year modules CHE101 and CHE103.
Learning outcomes 
Students completing the module successfully should:

A.have completed a number of different types of experiments including the use of protecting groups in organic transformations, the use of metal ions as "templates" in organic synthesis and the synthesis of organometallic and classical complexes of the transition metals.

B.have experience of the use of spectroscopic techniques (UV, IR, NMR and mass spectrometry) in the characterisation of organic and inorganic compounds and will be able to use analytical and spectroscopic methods to characterise their synthesised compounds.

C.be able to use word processing and chemical structure drawing programmes to produce written experimental reports.
Method of teaching and learning 
In this module students will be expected to complete a series of synthetic experiments. Each experiment will have a preliminary exercise (which includes a consideration of safety issues) which must be marked before the experiment is performed. On completion of the experiment, students must produce a writeup describing what was done and their results. This must be marked before the next experiment in undertaken. The teaching Laboratory will be open for nine hours per week. Students will be expected to organise their own time to complete the necessary experiments.


The laboratory sessions are complemented by a series of workshops on spectroscopic techniques. Students are expected to work through a series of exercises with the support of teaching staff. The knowledge gained in the workshops is tested by means of a class test at the end of the workshops.
Syllabus 
Organic Experiments (weeks 1-6)

Students are expected to complete satisfactorily three of the following experiments

-A Hantzsch pyridine synthesis.

-Synthesis of dimedone by carbonyl condensations.

-A Grignard reaction using a protecting group.

-Resolution of the enantiomers of 1-phenylethylamine.

Inorganic Experiments (weeks 7-12)

Students are expected to complete satisfactorily three preparations from

-Preparation and analysis of iron(II) oxalate.

-Preparation and analysis of acetylacetonato-complexes of transition-metals.

-Preparation of a cobaltammine and the determination of its molecular formula.

-Preparation and characterisation of a tetra-azamacrocycle complex of Ni(II).

Workshops (weeks 1 - 11)

Each workshop will begin with a short lecture to introduce the topics covered. Students will then work through problem sheets with the guidance of the demonstrators.

The following material will be covered

-Introduction to the physical basis of NMR. Quantum numbers, energy levels, magnetic equivalence, chemical shifts, scalar couplings. Revision of CHE102 material.

-The students will be asked to fill in the blanks for sequences of synthetic reaction schemes and explain the outcome and selectivity of reactions by use of the analytical data supplied to them. Interpretation of mass spectra, infrared spectra, elemental analyses and 1H and 13C NMR spectra will be required to determine structures.

-Spin-spin coupling (J values) in 1H NMR and their use in the determination of stereochemistry and conformational analysis will be introduced.

Delivery Hours  
Lectures Seminars Tutorials Lab/Prcaticals Fieldwork / Placement Other(Private study) Total
Hours/Semester 30       99    21  150 

Assessment

Sequence Method % of Final Mark
1 Lab Work 70.00
2 Organic Workshops 15.00
3 Inorganic Workshops 15.00

Module Catalogue generated from SITS CUT-OFF: 10/22/2017 9:32:18 PM